|
KMID : 1134820150440060800
|
|
Journal of the Korean Society of Food Science and Nutrition
2015 Volume.44 No. 6 p.800 ~ p.808
|
|
|
Inhibitory Activities of Ethanol Extracts from Saururus chinensis L. against Stress-Induced Hemorrhagic Gastritis
|
|
Park So-Young
Cho Young-Je
|
|
|
Abstract
|
|
|
|
In this study, gastritis inhibitory substance was ethanolextracted from Saururus chinensis in order to examine the effect as a part of natural bioactive substance research. In an oral administration experiment, S. chinensis was administered at doses of 0.25 g/kg B.W. to 2 g/kg B.W., resulting in stabilization at 1.5 g/kg B.W. and an LD50 of 1.81 g/kg B.W. In a chronic toxicity experiment, 0.5 g/kg B.W. of S. chinensis was administered for 13 weeks, but toxicity was not observed. S. chinensis ethanolextracts were administered at a concentration of 250 or 500 mg/kg B.W. before induction of gastritis. Gastrorrhagia, stomach edema, cytokine production, and cell damage were reduced in a concentrationdependent manner. Therefore, S. chinensis ethanol extracts inhibit cell damage by stress-induced hemorrhagic gastritis in a concentrationdependent manner via inhibition of cytokine expression.
|
|
|
KEYWORD
|
|
|
inhibitory activity, stress-induced hemorrhagic gastritis, Saururus chinensis, extracts
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|